Evaluate people obtaining acetaminophen and codeine phosphate tablets and any CYP2D6 inhibitor for indications and signs and symptoms that could reflect opioid toxicity and opioid withdrawal when acetaminophen and codeine phosphate tablets are applied along side inhibitors of CYP2D6.
This may be affiliated with a decrease in efficacy, and in a few patients, might bring about signals and indicators of opioid withdrawal.
Educate people and caregivers on how to recognize respiratory depression and emphasize the value of contacting 911 or receiving emergency professional medical support without delay from the function of the regarded or suspected overdose (see Safeguards, Info for Patients/Caregivers).
When this medication is used for many years, it may not work in addition. Speak with your health practitioner if this medication stops Doing the job perfectly.
If an individual has overdosed and has severe symptoms like passing out or difficulties breathing, provide them with naloxone if obtainable, then contact 911. If the individual is awake and has no indications, get in touch with a poison Handle Middle right away.
Evaluate Every individual’s threat for opioid habit, abuse, or misuse previous to prescribing acetaminophen and codeine phosphate tablets, and reassess all people receiving acetaminophen and codeine phosphate tablets for the development of those behaviors and circumstances. Hazards are improved in sufferers with a private or loved ones heritage of compound abuse (together with drug or alcohol abuse or addiction) or mental ailment (e.g., major melancholy). The likely for these risks should not, even so, protect against the appropriate administration of agony in any offered affected person.
Are already advised by your healthcare more info provider that you're a “rapid metabolizer” of specific medicines.
An opioid click hereget more info ache medicine that could put you in danger for overdose check here and Loss of life. Even though you take your dose the right way as prescribed, you might be at risk for opioid dependancy, abuse, and misuse that can cause Demise.
If concomitant use is warranted, routinely Examine the affected person, significantly throughout cure initiation and dose adjustment. Discontinue acetaminophen and codeine phosphate tablets immediately if serotonin syndrome is suspected.
These outcomes appear to improve Along with the duration of remedy. The clinical importance of these results will not be regarded.
Independently titrate acetaminophen and codeine phosphate tablets into a dose that provides sufficient analgesia and minimizes adverse reactions. Continuously reevaluate clients receiving acetaminophen and codeine phosphate tablets to evaluate the upkeep of ache Manage, indicators and symptoms of opioid withdrawal, and various adverse reactions, and also reassessing for the development of dependancy, abuse, or misuse (see WARNINGS).
Respiratory despair can happen Anytime throughout opioid therapy, specially when initiating and following dosage boosts with acetaminophen and codeine phosphate tablets. Consider this risk when deciding on an initial dose and when producing dose adjustments (see WARNINGS).
If you're getting this medication on a daily agenda and also you overlook a dose, choose it as soon as you remember. If it is near some time of the following dose, skip the missed dose. Consider your future dose on the common time. Will not double the dose to catch up.
Other pain relievers (including naproxen, ibuprofen) may additionally be prescribed with this medication. Inquire your medical doctor or pharmacist about utilizing this solution securely with other more info medications.